SDT fatty/Jcl
Animals/Diabetes Models/
Ordering name: SDT fatty/Jcl
Nomenclature: SDT.Cg-Leprfa/JttJcl
Availability: Live colony
Not genetically modified animal
Origin
In 2004, Dr. Masuyama and Dr. Shinohara (Research Laboratories of Torii Pharmaceutical Co., Ltd., Japan) established the congenic type 2 diabetes model Spontaneously Diabetic Torii fatty (SDT fatty) rat by introducing the fa allele of the Zucker Fatty rat into the genome of the original SDT rat 1). SDT fatty rats were introduced to Central Pharmaceutical Research Institute, Japan Tobacco Inc. (Japan) and were characterized in detail by Dr. Ohta and Dr. Sasase. CLEA Japan has received right of production and sales from Japan Tobacco Inc., and has distributed the animals as SDT fatty rats from 2012.
Background Data (weight, blood property, blood biochemistry, organ weight)
- SDT fatty/Jcl 10 weeks of age data (*Japanese)
- References (*Japanese)
Characteristics/Usage
Model Highlights (from Study Data)
Key findings extracted from the detailed study reports are summarized below.
【Diabetic Nephropathy Model】
Rapid Diabetic Nephropathy Model in SDT Fatty Rats
10-week protocol showing >50% GFR decline and severe renal fibrosis, enabling fast evaluation of anti-diabetic nephropathy therapies.
▼ 10-week 0.3% salt load + unilateral nephrectomy in SDT fatty rats
Creatinine clearance decreased and GFR declined by more than 50%.
Download Detailed Study (Japanese)
【NASH Model】
Cholesterol-Loaded SDT Fatty Rat Model of NASH
Induces steatosis, inflammation, and progressive liver fibrosis within 16～24 weeks, mimicking human NASH with type 2 diabetes and obesity.
▼ Jcl:SD cholesterol-added diet (Cho)
▼ SDT fatty/Jcl cholesterol-added diet (Cho)
Download Detailed Study (Japanese)
PDF Catalog
Model Overview & Pathology Summary
Key pathological and metabolic characteristics of SDT fatty rats are summarized below.
SDT Fatty Rat: Obese Type 2 Diabetes Model with Early Complications
Comprehensive model of obesity, hyperglycemia, nephropathy, neuropathy, and metabolic syndrome for preclinical diabetes research.
▽ Pathology of SDT fatty rat
Download Full English Catalog (PDF)
Additional Data 2023
Reference
▼ Introduction of Various Diabetic Complications model (Nephrology, Retinopathy, and Cardiovascular)
▼ Secondary Sarcopenia: SDT fatty rat, spontaneous type 2 diabetic animal model
▼ Cholesterol-Loaded NASH: SDT fatty rats, type 2 diabetes and obesity model
▼ High-sucrose/high-fat diet promotes nephropathy: Introduction of obese type 2 diabetes model SDT fatty rats
▼ Diabetic peripheral neuropathy in SDT fatty rat, a new animal model of obese type 2 diabetes
▼ The results of research on Diabetic Retinopathy in SDT fatty rats
Cautions for the Breeding and Experimentation of Diabetic Model Animals
- Acclimation: Please take 3-5 days of acclimation after transportation to avoid hypoglycemia caused by stress.
- Frequent Bedding Changes: Due to polyuria associated with diabetes, please increase the frequency and amount of bedding changes.
- Consistent Measurement: Blood glucose levels can fluctuate based on diet, measurement methods, and sample type (blood, serum, plasma). Please ensure consistent procedures.
Our Contract Research Services related with This Animal
For details on our contract research services, including cryopreserved embryos, contracted testing, and the provision of research materials such as blood and organs, please click here .
FAQ
What is SDT fatty/Jcl?
SDT fatty/Jcl is a type 2 diabetes model rat. Ordering name: SDT fatty/Jcl. Nomenclature: SDT.Cg-Leprfa/JttJcl.
Is SDT fatty/Jcl genetically modified?
No. SDT fatty/Jcl is a Not genetically modified animal.
What is the availability of SDT fatty/Jcl?
Availability is listed as Live colony.
Where can I find background data and references for SDT fatty/Jcl?
The page provides a PDF link for SDT fatty/Jcl 10 weeks of age data (weight, blood property, blood biochemistry, organ weight) and a link to the Academic Reference Archive for SDT fatty rats.
What precautions should be taken when breeding and experimenting with SDT fatty/Jcl?
Please allow 3～5 days of acclimation after transportation, increase the frequency and amount of bedding changes due to polyuria, and ensure consistent procedures when measuring blood glucose levels.
Inquiry
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